ea0029oc13.4 | Adrenal Basic | ICEECE2012
Assie G.
, Barreau O.
, Wilmot-Roussel H.
, Ragazzon B.
, Baudry C.
, Perlemoine K.
, Rene-Corail F.
, Dousset B.
, Bertagna X.
, Tissier F.
, De Reynies A.
, Bertherat J.
Introduction: DNA methylation is a mechanism for gene expression dysregulation in cancer. Little is known about methylation in adrenocortical tumors (ACT). Previous transcriptome studies proposed an original classification of ACT, first discriminating carcinomas from adenomas, then separating the carcinomas in two groups with different prognosis (C1A and C1B), the poor outcome group (C1A) being divided in three subgroups: p53 inactivation sub-group (C1Ap53), β-catenin act...